Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells

@article{Eggert2000MolecularDO,
  title={Molecular dissection of TrkA signal transduction pathways mediating differentiation in human neuroblastoma cells},
  author={Angelika Eggert and Naohiko Ikegaki and Xing-ge Liu and Thomas Chou and Virginia M-Y Lee and John Q. Trojanowski and Garrett M. Brodeur},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={2043-2051}
}
Activation of the neurotrophin receptor TrkA by its ligand nerve growth factor (NGF) initiates a cascade of signaling events leading to neuronal differentiation in vitro and might play an important role in the differentiation of favorable neuroblastomas (NB) in vivo. To study TrkA signal transduction pathways and their effects on differentiation in NB, we stably expressed wild-type TrkA and five different TrkA mutants in the NGF unresponsive human NB cell line SH-SY5Y. Resulting clones were… CONTINUE READING