Molecular differences between wild-type Japanese encephalitis virus strains of high and low mouse neuroinvasiveness.

@article{Ni1996MolecularDB,
  title={Molecular differences between wild-type Japanese encephalitis virus strains of high and low mouse neuroinvasiveness.},
  author={Haolin Ni and Alan D. T. Barrett},
  journal={The Journal of general virology},
  year={1996},
  volume={77 ( Pt 7)},
  pages={1449-55}
}
Japanese encephalitis (JE) virus strain P3 was highly neurovirulent and neuroinvasive in weanling mice whereas two other JE virus strains, SA14/USA and S892, were only neurovirulent. Infectivity titrations of brains and sera showed that P3 virus multiplied faster and reached a higher infectivity titre than S892 virus following inoculation of viruses by the intraperitoneal (i.p.) route. The p.f.u./LD50 was 10(1.7) and 10(6.2) for P3 and S892 viruses respectively, following i.p. inoculation… CONTINUE READING