Molecular diagnostics of ADPKD coming of age.

  title={Molecular diagnostics of ADPKD coming of age.},
  author={Peter C. Harris and Sandro Rossetti},
  journal={Clinical journal of the American Society of Nephrology : CJASN},
  volume={3 1},
E ver since the first autosomal dominant polycystic kidney disease (ADPKD) gene was localized to a chromosomal interval (PKD1: 16p13.3) in 1985, brave souls have been performing molecular-based diagnostics (1). The enthusiasm was tempered by the discovery of a second gene (PKD2: 4q21) and suggestions of a third, with the realization that reliable linkage… CONTINUE READING