Molecular diagnostics in acute leukemias

@inproceedings{Bacher2009MolecularDI,
  title={Molecular diagnostics in acute leukemias},
  author={U. Bacher and S. Schnittger and C. Haferlach and T. Haferlach},
  booktitle={Clinical chemistry and laboratory medicine},
  year={2009}
}
  • U. Bacher, S. Schnittger, +1 author T. Haferlach
  • Published in
    Clinical chemistry and…
     2009
  • Medicine
    • Abstract Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) both represent highly heterogeneous entities on the basis of diverse cyto- and molecular genetic alterations with considerable influence on prognosis and therapeutic decisions. In recent years, insights into the complex network of molecular markers underlying this diversity have shown marked progress due to the detection of novel mutations, such as nucleophosmin gene (NPM1) in AML, and due to the description of… CONTINUE READING
    View on PubMed
    doi.org
    36 Citations
    Highly Influential Citations
    2
    Background Citations
    6
    Methods Citations
    4
    36 Citations
    Citation Type

    Citation Type

    Molecular-Based Classification of Acute Myeloid Leukemia and Its Role in Directing Rational Therapy
    • 10
    • Highly Influenced
    Pathology Consultation on Gene Mutations in Acute Myeloid Leukemia.
    • 10
    • PDF
    An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
    • 18
    • PDF
    Molecular characterization and testing in acute myeloid leukemia
    • 2
    • PDF
    Class III Receptor Tyrosine Kinases in Acute Leukemia – Biological Functions and Modern Laboratory Analysis
    • 16
    Molecular analysis of different FLT3-ITD mutations in acute myeloid leukemia
    • 30
    Landscape of TET2 mutations in acute myeloid leukemia
    • 176
    • PDF
    Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia
    • 3
    Mutation Status in Myeloid Malignancies Informs Clinical Insight
    Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts.
    • 129
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 73 REFERENCES
    Diagnostic pathways in acute leukemias: a proposal for a multimodal approach
    • 56
    Development of minimal residual disease-directed therapy in acute myeloid leukemia.
    • 87
    Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics
    • 125
    Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.
    • 1,471
    • PDF
    Molecular genetic pathways as therapeutic targets in acute myeloid leukemia.
    • T. Haferlach
    • Medicine
    • Hematology. American Society of Hematology. Education Program
    • 2008
    • 79
    Acute promyelocytic leukemia: recent advances in diagnosis and management.
    • 64
    • PDF
    Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia
    • 117
    • PDF
    BAALC expression predicts clinical outcome of de novo acute myeloid leukemia patients with normal cytogenetics: a Cancer and Leukemia Group B Study.
    • 241
    • PDF
    Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease.
    • 962
    • PDF
    Recent advances in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
    • 28