Molecular diagnostic markers for lung cancer in sputum and plasma.

@article{Wang2006MolecularDM,
  title={Molecular diagnostic markers for lung cancer in sputum and plasma.},
  author={Yi-Ching Wang and Han-Shui Hsu and Tsz-Pei Chen and Jung-Ta Chen},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1075},
  pages={
          179-84
        }
}
Lung cancer is the leading cause of cancer deaths worldwide. This study was designed to select multiple DNA markers, which have high sensitivity and specificity to serve as biomarkers for diagnosis of lung cancer. We examined the promoter hypermethylation of three tumor suppressor genes by methylation-specific PCR (MSP), and the instability of eight microsatellite markers by loss of heterozygosity (LOH) and microsatellite instability (MSI) analyses in lung tumor tissues and matched sputum… CONTINUE READING

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