• Biology, Medicine
  • Published in
    The Journal of infectious…
    2004
  • DOI:10.1086/422758

Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones.

@article{Djimde2004MolecularDO,
  title={Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones.},
  author={Abdoulaye A Djimde and Amagana Dolo and Amed Ouattara and Sira Diakit{\'e} and Christopher V. Plowe and Ogobara K. Doumbo},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 4},
  pages={
          853-5
        }
}
Plasmodium falciparum mutations pfcrt K76T and the dhfr/dhps "quintuple mutant" are molecular markers of resistance to chloroquine and sulfadoxine-pyrimethamine, respectively. During an epidemic of P. falciparum malaria in an area of political unrest in northern Mali, where standard efficacy studies have been impossible, we measured the prevalence of these markers in a cross-sectional survey. In 80% of cases of infection, pfcrt K76T was detected, but none of the cases carried the dhfr/dhps… CONTINUE READING

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