Molecular diagnosis of pancreas carcinoma.

  title={Molecular diagnosis of pancreas carcinoma.},
  author={T. Ming Chu},
  journal={Journal of clinical laboratory analysis},
  volume={11 4},
  • T. Ming Chu
  • Published 1997 in Journal of clinical laboratory analysis
Cellular protooncogenes, tumor suppressor genes (antioncogenes), and DNA mismatch repair mutators are generally the key molecular genetic biomarkers undergoing alterations during carcinogenesis, i.e., activation of oncogenes, inactivation of tumor suppressors, and DNA mismatch repair gene defects are essential events in cancer causation. In pancreas cancer, high incidence of oncogene K-ras point mutations at the codon 12th is associated with premalignant and malignant transformation. Mutation… CONTINUE READING
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