Molecular diagnosis of cerebral toxoplasmosis: comparing markers that determine Toxoplasma gondii by PCR in peripheral blood from HIV-infected patients.

@article{Mesquita2010MolecularDO,
  title={Molecular diagnosis of cerebral toxoplasmosis: comparing markers that determine Toxoplasma gondii by PCR in peripheral blood from HIV-infected patients.},
  author={Rafael Tonini Mesquita and Jos{\'e} Ernesto Vidal and Vera Lucia Pereira-Chioccola},
  journal={The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases},
  year={2010},
  volume={14 4},
  pages={346-50}
}
As cerebral toxoplasmosis is the most common cerebral focal lesion in AIDS patients, this study evaluated three PCR markers for diagnosis, since some limitations remain present, such as low parasite levels in some clinical samples. The molecular markers were B22-B23 and Tg1-Tg2 (based on the B1 gene) and Tox4-Tox5 (non-coding fragment, repeated 200-300-fold). DNA samples from 102 AIDS patients with previously known diagnosis were analyzed. The cerebral toxoplasmosis group was constituted of DNA… CONTINUE READING

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