Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects.

@article{Borlak2000MolecularDO,
  title={Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects.},
  author={J{\"u}rgen Borlak and Thomas Thum and Olfert Landt and Katharina Erb and R{\'o}bert Hermann},
  journal={Hepatology},
  year={2000},
  volume={32 4 Pt 1},
  pages={792-5}
}
Recent research has shown that congenital nonhemolytic low grade hyperbilirubinemias in patients with Gilbert's syndrome (GS) are linked to mutations in the TATA box upstream of the uridine 5'-diphosphoglucose glucuronosyltransferase (UGT1A1) gene leading to an impaired bilirubin glucuronidation. In routine clinical practice GS patients can, however, only be suspected by exclusion of other causes of hyperbilirubinemia or substantial liver diseases. We developed a new, sensitive, convenient, and… CONTINUE READING

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