Molecular diagnosis in Ewing family tumors: the Rizzoli experience--222 consecutive cases in four years.

@article{Gamberi2011MolecularDI,
  title={Molecular diagnosis in Ewing family tumors: the Rizzoli experience--222 consecutive cases in four years.},
  author={Gabriella Gamberi and Stefania Cocchi and Stefania Benini and Giovanna Magagnoli and Luca Morandi and Jennifer L Kreshak and Marco Gambarotti and Piero Picci and Licciana Zanella and Marco Alberghini},
  journal={The Journal of molecular diagnostics : JMD},
  year={2011},
  volume={13 3},
  pages={
          313-24
        }
}
The Ewing's family of tumors (EFTs) are characterized by chimeric transcripts generated by specific chromosomal rearrangements. The most common fusions are between the EWSR1 gene on chromosome 22 and the ETS family of transcription factors; rarely, FUS (on chromosome 16) substitutes for EWSR1. The detection of specific translocations using molecular analysis is now a routine part of the pathological examination of EFT. Here, we report our experience with molecular diagnosis of EFT during the 4… CONTINUE READING

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