Molecular diagnosis and therapy of kidney cancer.

  title={Molecular diagnosis and therapy of kidney cancer.},
  author={W. Marston Linehan and Gennady Bratslavsky and Peter L Choyke and Laura S. Schmidt and Leonard M. Neckers and Donald P Bottaro and Ramaprasad Srinivasan},
  journal={Annual review of medicine},
Kidney cancer is not a single disease; it is made up of a number of cancers that occur in the kidney, each having a different histology, following a different clinical course, responding differently to therapy, and caused by a different gene. Study of the genes underlying kidney cancer has revealed that it is fundamentally a metabolic disorder. Understanding the genetic basis of cancer of the kidney has significant implications for diagnosis and management of this disease. VHL is the gene for… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 86 references

A phase II study of the dual MET/VEGFR2 inhibitor XL880 in patients (pts) with papillary renal carcinoma

R Srinivasan, TK Choueiri, U Vaishampayan
(PRC). J. Clin. Oncol. 26(May • 2008
View 4 Excerpts
Highly Influenced

Sorafenib in advanced clear-cell renal-cell carcinoma.

The New England journal of medicine • 2007
View 6 Excerpts
Highly Influenced

Sunitinib versus interferon alfa in metastatic renal-cell carcinoma.

The New England journal of medicine • 2007
View 7 Excerpts
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