Molecular determinants responsible for differences in desensitization kinetics of AMPA receptor splice variants.

@article{Quirk2004MolecularDR,
  title={Molecular determinants responsible for differences in desensitization kinetics of AMPA receptor splice variants.},
  author={Jennifer C Quirk and Edward Ryszard Siuda and E. Nisenbaum},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2004},
  volume={24 50},
  pages={
          11416-20
        }
}
Flip (i) and flop (o) alternatively spliced variants of the four glutamate AMPA receptor subunits (GluR1-4) are differentially expressed in the CNS and can display distinct rates of desensitization that contribute to the heterogeneity of native AMPA receptor-dependent synaptic responses. In the present study, we initially compared the kinetics of desensitization in response to fast application of glutamate (1 mm) for the eight different homomeric recombinant human AMPA receptors (hGluR1-4i and… CONTINUE READING

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