Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses.

@article{Griot1993MolecularDO,
  title={Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses.},
  author={C Griot and Francisco Gonz{\'a}lez-Scarano and Neal Nathanson},
  journal={Annual review of microbiology},
  year={1993},
  volume={47},
  pages={117-38}
}
California bunyaviruses cause encephalitis in mammalian hosts after peripheral infection. The virulence of these viruses is determined by their ability to replicate sequentially in striated muscle, cause viremia, and invade and replicate in the central nervous system. These viruses are also able to infect vector mosquitoes following ingestion of a blood meal containing virus. Bunyaviruses are negative stranded RNA viruses with a trisegmented genome, and the large, medium, and small RNA segments… CONTINUE READING
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