Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.

@article{Siu2008MolecularDO,
  title={Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.},
  author={Karen K W Siu and Jeffrey E. Lee and Janice R. Sufrin and Barbara A. Moffatt and Martin McMillan and Kenneth A Cornell and Chelsea A. Isom and P Lynne Howell},
  journal={Journal of molecular biology},
  year={2008},
  volume={378 1},
  pages={112-28}
}
5'-Methylthioadenosine (MTA)/S-adenosylhomocysteine (SAH) nucleosidase (MTAN) is essential for cellular metabolism and development in many bacterial species. While the enzyme is found in plants, plant MTANs appear to select for MTA preferentially, with little or no affinity for SAH. To understand what determines substrate specificity in this enzyme, MTAN homologues from Arabidopsis thaliana (AtMTAN1 and AtMTAN2, which are referred to as AtMTN1 and AtMTN2 in the plant literature) have been… CONTINUE READING