Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

@inproceedings{Brichta2014MolecularDO,
  title={Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update},
  author={Lars Brichta and Paul Greengard},
  booktitle={Front. Neuroanat.},
  year={2014}
}
Numerous disorders of the central nervous system (CNS) are attributed to the selective death of distinct neuronal cell populations. Interestingly, in many of these conditions, a specific subset of neurons is extremely prone to degeneration while other, very similar neurons are less affected or even spared for many years. In Parkinson's disease (PD), the motor manifestations are primarily linked to the selective, progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta… CONTINUE READING

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