Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.

@article{Varfolomeev2005MolecularDO,
  title={Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand.},
  author={Eugene Varfolomeev and Heather Maecker and Darcie A Sharp and David Lawrence and Mark E Renz and Domagoj Vucic and Avi Ashkenazi},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 49},
  pages={40599-608}
}
Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) mainly activates programmed cell death through caspases. By contrast, TNF primarily induces gene transcription through the inhibitor of kappaB kinase (IKK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase pathways. Apo2L/TRAIL also can stimulate these kinases, albeit less strongly; however, the underlying mechanisms of this stimulation and its relation to apoptosis are not well… CONTINUE READING
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