Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.

@article{Lynagh2011MolecularDO,
  title={Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.},
  author={Timothy Lynagh and Timothy I. Webb and Christine L. Dixon and Brett A Cromer and Joseph W Lynch},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 51},
  pages={43913-24}
}
Ivermectin is an anthelmintic drug that works by activating glutamate-gated chloride channel receptors (GluClRs) in nematode parasites. GluClRs belong to the Cys-loop receptor family that also includes glycine receptor (GlyR) chloride channels. GluClRs and A288G mutant GlyRs are both activated by low nanomolar ivermectin concentrations. The crystal structure of the Caenorhabditis elegans α GluClR complexed with ivermectin has recently been published. Here, we probed ivermectin sensitivity… CONTINUE READING
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Glycine Receptor Ivermectin-binding Site 43924 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • L. J. Greenfield, Jr., +5 authors R. L. andMacdonald
  • J. Biol. Chem. 10.1074/jbc.M111.262634
  • 2011

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