Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.

  title={Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channel.},
  author={Timothy Lynagh and Timothy I. Webb and Christine L. Dixon and Brett A Cromer and Joseph W Lynch},
  journal={The Journal of biological chemistry},
  volume={286 51},
Ivermectin is an anthelmintic drug that works by activating glutamate-gated chloride channel receptors (GluClRs) in nematode parasites. GluClRs belong to the Cys-loop receptor family that also includes glycine receptor (GlyR) chloride channels. GluClRs and A288G mutant GlyRs are both activated by low nanomolar ivermectin concentrations. The crystal structure of the Caenorhabditis elegans α GluClR complexed with ivermectin has recently been published. Here, we probed ivermectin sensitivity… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
20 Extracted Citations
1 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 20 extracted citations

Referenced Papers

Publications referenced by this paper.

Glycine Receptor Ivermectin-binding Site 43924 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • L. J. Greenfield, Jr., +5 authors R. L. andMacdonald
  • J. Biol. Chem. 10.1074/jbc.M111.262634
  • 2011

Similar Papers

Loading similar papers…