Molecular determinants of infectious pancreatic necrosis virus virulence and cell culture adaptation.

@article{Song2005MolecularDO,
  title={Molecular determinants of infectious pancreatic necrosis virus virulence and cell culture adaptation.},
  author={Haichen Song and Nina Santi and Oystein Evensen and Vikram N. Vakharia},
  journal={Journal of virology},
  year={2005},
  volume={79 16},
  pages={10289-99}
}
Infectious pancreatic necrosis viruses (IPNVs) exhibit a wide range of virulence in salmonid species. In previous studies, we have shown that the amino acid residues at positions 217 and 221 in VP2 are implicated in virulence. To pinpoint the molecular determinants of virulence in IPNV, we generated recombinant IPNV strains using the cRNA-based reverse-genetics system. In two virulent strains, residues at positions 217 and 247 were replaced by the corresponding amino acids of a low-virulence… CONTINUE READING

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