Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels.

@article{Ficker2001MolecularDO,
  title={Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels.},
  author={Eckhard K. Ficker and W. Jarolimek and Arthur M. Brown},
  journal={Molecular pharmacology},
  year={2001},
  volume={60 6},
  pages={1343-8}
}
The major subunit of the cardiac delayed rectifier current I(Kr) is encoded by the human ether a-go-go related gene (HERG). HERG/I(Kr) channels are blocked selectively by class III antiarrhythmic methanesulfonanilide drugs such as dofetilide. The binding site for methanesulfonanilides is believed to be similar for nonantiarrhythmic drugs such as antihistamines, antibiotics, and antipsychotics. To gain further insight into the binding site, we examined the minimal structural changes necessary to… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Molecular determinants of cocaine block of human ether-á-go-go-related gene potassium channels.

The Journal of pharmacology and experimental therapeutics • 2006
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 39 references

A structural basis for drug-induced long QT syndrome.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 8 Excerpts
Highly Influenced

Mechanisms of cardiac arrhythmias: focus on atrial fibrillation.

The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia • 2001
View 1 Excerpt

Molecular and

MT Keating, MC Sanguinetti
CELLULAR • 2001
View 1 Excerpt

Similar Papers

Loading similar papers…