Molecular determinants of immunogenicity: the immunon model of immune response.

  title={Molecular determinants of immunogenicity: the immunon model of immune response.},
  author={Howard M Dintzis and Renee Z. Dintzis and Bert Vogelstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={73 10},
The immunological response in vivo to a series of size-fractionated linear polymers of acrylamide substituted with hapten has been measured in mice. A sharp threshold was observed in immunogenic response elicited by various polymer preparations. All polymers with less than 12 to 16 appropriately spaced hapten groups per molecule were nonimmunogenic, while those polymers with greater than this number were fully immunogenic. The results lead to the conclusion that the immunological response at… CONTINUE READING

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