Molecular determinants of ginkgolide binding in the glycine receptor pore

  title={Molecular determinants of ginkgolide binding in the glycine receptor pore},
  author={Rebecca Hawthorne and B. Cromer and Hooi-Ling Ng and M. Parker and J. W. Lynch},
  journal={Journal of Neurochemistry},
  • Rebecca Hawthorne, B. Cromer, +2 authors J. W. Lynch
  • Published 2006
  • Chemistry, Medicine
  • Journal of Neurochemistry
  • Ginkgolides are potent blockers of the glycine receptor Cl– channel (GlyR) pore. We sought to identify their binding sites by comparing the effects of ginkgolides A, B and C and bilobalide on α1, α2, α1β and α2β GlyRs. Bilobalide sensitivity was drastically reduced by incorporation of the β subunit. In contrast, the sensitivities to ginkgolides B and C were enhanced by β subunit expression. However, ginkgolide A sensitivity was increased in the α2β GlyR relative to the α2 GlyR but not in the α1… CONTINUE READING
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