Molecular determinants of gating at the potassium-channel selectivity filter

@article{CorderoMorales2006MolecularDO,
  title={Molecular determinants of gating at the potassium-channel selectivity filter},
  author={Julio F. Cordero-Morales and Luis G Cuello and Yanxiang Zhao and Vishwanath Jogini and D. Marien Cortes and Beno{\^i}t Roux and Eduardo Perozo},
  journal={Nature Structural &Molecular Biology},
  year={2006},
  volume={13},
  pages={311-318}
}
We show that in the potassium channel KcsA, proton-dependent activation is followed by an inactivation process similar to C-type inactivation, and this process is suppressed by an E71A mutation in the pore helix. EPR spectroscopy demonstrates that the inner gate opens maximally at low pH regardless of the magnitude of the single-channel-open probability… CONTINUE READING