Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.

@article{Miller2015MolecularDO,
  title={Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.},
  author={Mark S. Miller and Nicholas G Bedrin and Philip A. Ades and Bradley M. Palmer and Michael J. Toth},
  journal={American journal of physiology. Cell physiology},
  year={2015},
  volume={308 6},
  pages={C473-84}
}
Skeletal muscle contractile performance is governed by the properties of its constituent fibers, which are, in turn, determined by the molecular interactions of the myofilament proteins. To define the molecular determinants of contractile function in humans, we measured myofilament mechanics during maximal Ca(2+)-activated and passive isometric conditions in single muscle fibers with homogenous (I and IIA) and mixed (I/IIA and IIA/X) myosin heavy chain (MHC) isoforms from healthy, young adult… CONTINUE READING
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