Molecular determinants of dysplasia in colorectal lesions.

  title={Molecular determinants of dysplasia in colorectal lesions.},
  author={Jin Jen and Steven M. Powell and Nickolas Papadopoulos and Kenneth J. Smith and Stanley R. Hamilton and Bert Vogelstein and Ken W Kinzler},
  journal={Cancer research},
  volume={54 21},
One hallmark of malignant potential is dysplasia, the disruption of normal morphology. While it is generally recognized that cancer is the result of a series of genetic changes, the relationship of these alterations and their timing to the advent of dysplasia remains obscure. To address this issue, 54 small benign colorectal lesions of various malignant potential were analyzed for APC and K-RAS mutations, two alterations which have been implicated in the early stages of colorectal tumorigenesis… CONTINUE READING

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