Molecular determinants of drug binding and action on L-type calcium channels.

@article{Hockerman1997MolecularDO,
  title={Molecular determinants of drug binding and action on L-type calcium channels.},
  author={Gregory H Hockerman and Blaise Z. Peterson and Brody Dylan Johnson and William A. Catterall},
  journal={Annual review of pharmacology and toxicology},
  year={1997},
  volume={37},
  pages={
          361-96
        }
}
  • Gregory H Hockerman, Blaise Z. Peterson, +1 author William A. Catterall
  • Published in
    Annual review of pharmacology…
    1997
  • Chemistry, Medicine
  • The crucial role of L-type Ca2+ channels in the initiation of cardiac and smooth muscle contraction has made them major therapeutic targets for the treatment of cardiovascular disease. L-type channels share a common pharmacological profile, including high-affinity voltage- and frequency-dependent block by the phenylalkylamines, the benz(othi)azepines, and the dihydropyridines. These drugs are thought to bind to three separate receptor sites on L-type Ca2+ channels that are allosterically linked… CONTINUE READING

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