Molecular determinants of cardiac K(ATP) channel activation by epoxyeicosatrienoic acids.

@article{Lu2005MolecularDO,
  title={Molecular determinants of cardiac K(ATP) channel activation by epoxyeicosatrienoic acids.},
  author={Tong Lu and Min-Pyo Hong and Hon-chi Lee},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 19},
  pages={19097-104}
}
We have previously reported that epoxyeicosatrienoic acids (EETs), the cytochrome P450 epoxygenase metabolites of arachidonic acid, are potent stereospecific activators of the cardiac K(ATP) channel. The epoxide group in EET is critical for reducing channel sensitivity to ATP, thereby activating the channel. This study is to identify the molecular sites on… CONTINUE READING