Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding.

@article{Wei1995MolecularDO,
  title={Molecular determinants of cardiac Ca2+ channel pharmacology. Subunit requirement for the high affinity and allosteric regulation of dihydropyridine binding.},
  author={Xianying Wei and Sheng-li Pan and Wenhua Lang and Heeman Kim and Toni Schneider and Edward Perez-Reyes and Lutz Birnbaumer},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 45},
  pages={
          27106-11
        }
}
Cardiac L-type Ca2+ channels are multisubunit complexes composed of alpha 1C, alpha 2 delta, and beta 2 subunits. We tested the roles of these subunits in forming a functional complex by characterizing the effects of subunit composition on dihydropyridine binding, its allosteric regulation, and the ability of dihydropyridines to inhibit channel activity. Transfection of COS.M6 cells with cardiac alpha 1C-a (alpha 1) led to the appearance of dihydropyridine ([3H]PN200-110) binding which was… CONTINUE READING
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