Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation.

@article{ElArmouche2006MolecularDO,
  title={Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation.},
  author={Ali El-Armouche and Peter Bokn{\'i}k and Thomas Eschenhagen and Lucie Carrier and Michael Knaut and Ursula Ravens and Dobromir Dobrev},
  journal={Circulation},
  year={2006},
  volume={114 7},
  pages={
          670-80
        }
}
BACKGROUND Abnormal Ca2+ handling may contribute to impaired atrial contractility and arrhythmogenesis in human chronic atrial fibrillation (cAF). Here, we assessed the phosphorylation levels of key proteins involved in altered Ca2+ handling and contractility in cAF patients. METHODS AND RESULTS Total and phosphorylation levels of Ca2+-handling and myofilament proteins were analyzed by Western blotting in right atrial appendages of 49 patients in sinus rhythm and 52 cAF patients. We found a… CONTINUE READING

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