Molecular determinants of TRP channel assembly.

  title={Molecular determinants of TRP channel assembly.},
  author={Pascale K Lepage and G. H. de Boulay},
  journal={Biochemical Society transactions},
  volume={35 Pt 1},
Calcium channels play important roles in cellular signalling. TRP (transient receptor potential) channels form a superfamily of calcium channels through which Ca(2+) enters the cell. TRPs have six transmembrane segments with a putative pore between the fifth and the sixth segments, and assemble in tetrameric complexes to form functional Ca(2+) channels. They are thus similar to K(V) (voltage-gated potassium channel) channels in terms of structure and molecular determinants that promote subunit… CONTINUE READING

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