Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2

Abstract

The inhibitors of apoptosis (IAP) proteins cIAP1 and cIAP2 have recently emerged as key ubiquitin-E3 ligases regulating innate immunity and cell survival. Much of our knowledge of these IAPs stems from studies using pharmacological inhibitors of IAPs, dubbed Smac mimetics (SMs). Although SMs stimulate auto-ubiquitylation and degradation of cIAPs, little is… (More)
DOI: 10.1038/cdd.2011.10

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Cite this paper

@inproceedings{Darding2011MolecularDO, title={Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2}, author={Maurice Darding and R. K. A. Feltham and Tichomir Tenev and Katiuscia Bianchi and Christopher A. Benetatos and John Silke and Petra Meier}, booktitle={Cell Death and Differentiation}, year={2011} }