Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers.

@article{Liang2009MolecularDO,
  title={Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers.},
  author={Yuying Liang and Shuiyun Lan and Hinh Ly},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1171 Suppl 1},
  pages={E65-74}
}
Arenaviruses are enveloped single-strand RNA viruses that mostly have natural hosts in rodents. Upon infection of humans, several arenaviruses can cause severe hemorrhagic fever diseases, including Lassa fever that is endemic in West Africa. The virulence mechanism of these deadly arenaviruses can be studied in a safe and economical small animal model-guinea pigs infected by a nonpathogenic arenavirus Pichinde virus (PICV), a virulent strain of which can cause similar disease syndromes in… CONTINUE READING

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References

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Showing 1-10 of 48 references

Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses.

Proceedings of the National Academy of Sciences of the United States of America • 2008

Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus

L Martinez-Sobrido
J. Virol • 2006

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