Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit.

@article{McCormick1998MolecularDO,
  title={Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit.},
  author={Kimberly A. McCormick and Lori L Isom and David S. Ragsdale and Daniel Smith and Todd Scheuer and William A. Catterall},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 7},
  pages={3954-62}
}
The rat brain voltage-gated Na+ channel is composed of three glycoprotein subunits: the pore-forming alpha subunit and two auxiliary subunits, beta1 and beta2, which contain immunoglobulin (Ig)-like folds in their extracellular domains. When expressed in Xenopus oocytes, beta1 modulates the gating properties of the channel-forming type IIA alpha subunit, resulting in an acceleration of inactivation. We have used a combination of deletion, alanine-scanning, site-directed, and chimeric… CONTINUE READING

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