Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels.

@article{Leipold2011MolecularDF,
  title={Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels.},
  author={Enrico Leipold and Ren{\'e} Markgraf and Alesia A Miloslavina and Michael Kijas and Jana Schirmeyer and Diana Imhof and Stefan H. Heinemann},
  journal={Neuropharmacology},
  year={2011},
  volume={61 1-2},
  pages={105-11}
}
Voltage-gated sodium channels (Na(V) channels) play a pivotal role in neuronal excitability; they are specifically targeted by μ-conotoxins from the venom of marine cone snails. These peptide toxins bind to the outer vestibule of the channel pore thereby blocking ion conduction through Na(V) channels. μ-Conotoxin SIIIA from Conus striatus was shown to be a potent inhibitor of neuronal sodium channels and to display analgesic effects in mice, albeit the molecular targets are not unambiguously… CONTINUE READING

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