Molecular determinants for subcellular localization of hepatitis C virus core protein.

@article{Suzuki2005MolecularDF,
  title={Molecular determinants for subcellular localization of hepatitis C virus core protein.},
  author={Ryosuke Suzuki and Shinichiro Sakamoto and Takeya Tsutsumi and Akiko Rikimaru and Keiko Tanaka and Takashi Shimoike and Kohji Moriishi and Takuya Iwasaki and Kiyohisa Mizumoto and Yoshiharu Matsuura and Tatsuo Miyamura and Tetsuro Suzuki},
  journal={Journal of virology},
  year={2005},
  volume={79 2},
  pages={1271-81}
}
Hepatitis C virus (HCV) core protein is a putative nucleocapsid protein with a number of regulatory functions. In tissue culture cells, HCV core protein is mainly located at the endoplasmic reticulum as well as mitochondria and lipid droplets within the cytoplasm. However, it is also detected in the nucleus in some cells. To elucidate the mechanisms by which cellular trafficking of the protein is controlled, we performed subcellular fractionation experiments and used confocal microscopy to… CONTINUE READING
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