Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virus.

@article{Avila2014MolecularDD,
  title={Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virus.},
  author={Mislay Avila and Lisa A Alves and Mojtaba Khosravi and Nadine Ader-Ebert and Francesco Carlo Origgi and J{\"u}rgen Schneider-Schaulies and Andreas Zurbriggen and Richard K Plemper and Philippe Plattet},
  journal={Journal of virology},
  year={2014},
  volume={88 5},
  pages={2951-66}
}
UNLABELLED The morbillivirus cell entry machinery consists of a fusion (F) protein trimer that refolds to mediate membrane fusion following receptor-induced conformational changes in its binding partner, the tetrameric attachment (H) protein. To identify molecular determinants that control F refolding, we generated F chimeras between measles virus (MeV) and canine distemper virus (CDV). We located a central pocket in the globular head domain of CDV F that regulates the stability of the… CONTINUE READING