Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease.

@article{Mori1996MolecularDO,
  title={Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease.},
  author={Masaki Mori and Koshi Mimori and Hiroaki Ueo and Nobuya Karimine and Graham F. Barnard and Keizo Sugimachi and Tsuyoshi Akiyoshi},
  journal={International journal of cancer},
  year={1996},
  volume={68 6},
  pages={739-43}
}
Detection of the mRNA of selected genes by reverse transcriptase-polymerase chain reaction (RT-PCR) is a sensitive and powerful tool for detecting cancer cells in bone-marrow or peripheral-blood samples. In this study, we determined whether carcinoembryonic antigen (CEA) mRNA is detectable in the peripheral blood of patients with gastrointestinal or breast cancer. In addition, we studied selected patients undergoing surgical procedures to assess whether tumor manipulation during operation… CONTINUE READING

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