Molecular detection of cancer cells in the peripheral blood of patients with breast cancer: comparison of CK-19, CEA and maspin as detection markers.

@article{Stathopoulou2003MolecularDO,
  title={Molecular detection of cancer cells in the peripheral blood of patients with breast cancer: comparison of CK-19, CEA and maspin as detection markers.},
  author={Aliki Stathopoulou and Dimitrios Mavroudis and Maria Perraki and Stella Apostolaki and Ioannis Vlachonikolis and Evi S. Lianidou and Vassilis Georgoulias},
  journal={Anticancer research},
  year={2003},
  volume={23 2C},
  pages={1883-90}
}
PURPOSE To investigate and compare the diagnostic value of the detection of cytokeratin 19 (CK-19), carcinoembryonic antigen (CEA) and maspin mRNA by nested RT-PCR in the peripheral blood of women with breast cancer. MATERIALS AND METHODS The tumor cell lines MCF-7 and LOVO were used in an experimental tumor cell dilution model to determine the sensitivity of the nested RT-PCR for the 3 detection markers. RT-PCR analysis was performed in the peripheral blood of 54 healthy female blood donors… CONTINUE READING

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