Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes.

@article{Koch1994MolecularDA,
  title={Molecular detection and characterization of clonal cell populations in acute lymphocytic leukemia by analysis of conformational polymorphisms of cRNA molecules of rearranged T-cell-receptor-gamma and immunoglobulin heavy-chain genes.},
  author={Olaf M Koch and Matthias Volkenandt and Erdem G{\"o}ker and Jan Buer and Mario C O Probst and Debabrata Banerjee and Peter V. Danenberg and J R Bertino},
  journal={Leukemia},
  year={1994},
  volume={8 6},
  pages={946-52}
}
Junctional regions of rearranged T-cell-receptor-gamma (TCR) and immunoglobulin heavy-chain (IgH) genes represent an idiotypic DNA sequence for an individual lymphocytic cell, and any clone or clonal disease developing from this cell. In this study, a novel methodology for detection and characterization of clone specific DNA sequences in patients with acute… CONTINUE READING