Molecular details of formin-mediated actin assembly.

  title={Molecular details of formin-mediated actin assembly.},
  author={D. Kovar},
  journal={Current opinion in cell biology},
  volume={18 1},
  • D. Kovar
  • Published 2006
  • Biology, Medicine
  • Current opinion in cell biology
  • Formins are a large family of multi-domain polypeptides that form homodimers. The highly conserved formin homology 2 (FH2) domain and its neighboring formin homology 1 (FH1) domain, which are surrounded by regulatory domains, cooperate in rapidly assembling profilin-actin into long filaments while remaining continuously associated with the fast-growing barbed end. Recent biochemical, biophysical, theoretical and structural studies have concluded that diverse formins are mechanistically similar… CONTINUE READING
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