Molecular design of new sodium channel blockers.

  title={Molecular design of new sodium channel blockers.},
  author={P. Li and Shunyi Zhu},
  journal={Biochemical and biophysical research communications},
  volume={414 2},
  • P. Li, Shunyi Zhu
  • Published 2011
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
Animal toxins targeting voltage-gated sodium channels (VGSCs) have been considered as valuable tools for studying pharmacological functions of VGSCs. Recently we have reported that Drosotoxin (DrTx), an evolution-guided chimeric peptide, exhibits highly selective blocking activity to tetrodotoxin-resistant (TTX-R) Na(+) channels in rat dorsal root ganglion (DRG) neurons. In this study, we constructed five new analogues of DrTx designed by altering amino-terminal sequences of DrTx, two of which… Expand


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