Molecular design, synthesis and anticoagulant activity evaluation of fluorinated dabigatran analogues.


In the present study, a series of unreported fluorinated dabigatran analogues, which were based on the structural scaffold of dabigatran, were designed by computer-aided simulation. Fifteen fluorinated dabigatran analogues were screened and synthesized. All target compounds were characterized by (1)H NMR, (13)C NMR, (19)F NMR and HRMS. According to the… (More)
DOI: 10.1016/j.bmc.2016.04.038