Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione.

@article{Lee2005MolecularDS,
  title={Molecular design, synthesis, and hypoglycemic and hypolipidemic activities of novel pyrimidine derivatives having thiazolidinedione.},
  author={Hong Woo Lee and Bok Young Kim and Joong Bok Ahn and Sung Kwon Kang and Jung Hwa Lee and Jae Soo Shin and Soon Kil Ahn and Sang Joon Lee and Seung Soo Yoon},
  journal={European journal of medicinal chemistry},
  year={2005},
  volume={40 9},
  pages={862-74}
}
We previously reported the synthesis and biological activity of novel substituted pyridines and purines having thiazolidinedione with hypoglycemic and hypolipidemic activities. We now report the synthesis and antidiabetic activity of novel substituted pyrimidines having thiazolidinedione moiety. These compounds (entry No. 5a-i, 10a-d and 16) were evaluated for their glucose and lipid lowering activity in KKA(y) mice. From the results, novel compounds, 5c and 5g, exhibited considerably more… CONTINUE READING
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