Molecular deletion of 9p sequences in non-small cell lung cancer and malignant mesothelioma.

@article{Center1993MolecularDO,
  title={Molecular deletion of 9p sequences in non-small cell lung cancer and malignant mesothelioma.},
  author={Rob J Center and R E Lukeis and E. Dietzsch and Marc Gillespie and O. Margaret Garson},
  journal={Genes, chromosomes & cancer},
  year={1993},
  volume={7 1},
  pages={47-53}
}
Previously we have reported non-random cytogenetic abnormalities involving the short arm of chromosome 9 (9P) in the majority of primary non-small cell lung cancer (NSCLC) patient samples, which indicated loss of DNA sequences. In another lung tumor, pleural malignant mesothelioma (MM), cytogenetic changes also include apparent deletions of 9p. To define the location and extent of deletions of 9p in NSCLC and MM, Southern blot analyses on six NSCLC and five MM cell lines using molecular probes… CONTINUE READING