Molecular definition of chromosome translocations involving 10q24 and 19q13 in human malignant glioma cells.

@article{Chernova1998MolecularDO,
  title={Molecular definition of chromosome translocations involving 10q24 and 19q13 in human malignant glioma cells.},
  author={Olga B. Chernova and John K Cowell},
  journal={Cancer genetics and cytogenetics},
  year={1998},
  volume={105 1},
  pages={60-8}
}
Loss of heterozygosity (LOH) analysis has repeatedly implicated the 10q24-26 region as the site of tumor suppressor genes involved in the development of malignant human gliomas. However, deletions of this kind are generally too big to pinpoint the critical genes involved. On the other hand, chromosome translocations frequently interrupt genes important in… CONTINUE READING