Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle

@article{Grobet2009MolecularDO,
  title={Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle},
  author={Luc Grobet and Dominique Poncelet and Luis J Royo and Beno{\^i}t Brouwers and Dimitri Pirottin and Charles Michaux and François M{\'e}nissier and Marta Zanotti and Susana Dunner and Michel Georges},
  journal={Mammalian Genome},
  year={2009},
  volume={9},
  pages={210-213}
}
We have determined the entire myostatin coding sequence for 32 double-muscled cattle sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified, of which five would be predicted to disrupt the function of the protein, one is a conservative amino acid substitution, and one a silent DNA sequence variant. Four additional DNA sequence polymorphisms were identified in myostatin intronic sequences. In all but two breeds, all double-muscled animals were either homozygous… Expand
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