Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease.

@article{Treci1997MolecularDO,
  title={Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease.},
  author={Ozlem T{\"u}reci and Holly C Schmitt and Natalie Fadle and Michael Pfreundschuh and Ugur Sahin},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 10},
  pages={6416-22}
}
Using autologous serum for the immunoscreening of a cDNA expression library derived from tissue involved by Hodgkin's disease, a new 36-kDa protein with the characteristics of galectins (S-type lectins) was detected. Sequence analysis of the cDNA clone HOM-HD-21 revealed two homologous motifs known as lectin domains with galactoside binding capacity. The two domains are linked by a stretch of about 30 amino acid residues and share a sequence homology of 39%. While the N-terminal lectin domain… CONTINUE READING

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