Molecular decomposition of complex clinical phenotypes using biologically structured analysis of microarray data

@article{Lottaz2005MolecularDO,
  title={Molecular decomposition of complex clinical phenotypes using biologically structured analysis of microarray data},
  author={Claudio Lottaz and Rainer Spang},
  journal={Bioinformatics},
  year={2005},
  volume={21 9},
  pages={1971-8}
}
MOTIVATION Today, the characterization of clinical phenotypes by gene-expression patterns is widely used in clinical research. If the investigated phenotype is complex from the molecular point of view, new challenges arise and these have not been addressed systematically. For instance, the same clinical phenotype can be caused by various molecular disorders, such that one observes different characteristic expression patterns in different patients. RESULTS In this paper we describe a novel… CONTINUE READING
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Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles

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