Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph+ adult acute lymphoblastic leukaemia.

@article{Specchia2002MolecularCC,
  title={Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph+ adult acute lymphoblastic leukaemia.},
  author={Giorgina Specchia and Francesco Albano and Luisa Anelli and Clelia Tiziana Storlazzi and Giuseppe Cimino and Arcangelo Liso and Antonella Zagaria and Vincenzo Liso and Mariano Rocchi},
  journal={British journal of haematology},
  year={2002},
  volume={119 2},
  pages={488-91}
}
We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resulting from this novel translocation, and its possible role in the progression of the leukaemia is discussed.