Molecular cytogenetic identification of four X chromosome duplications.

  title={Molecular cytogenetic identification of four X chromosome duplications.},
  author={Aijun Zhang and David D. Weaver and Catherine G. Palmer},
  journal={American journal of medical genetics},
  volume={68 1},
Four cases with previously unidentified X-chromosome abnormalities were studied by standard cytogenetic techniques and FISH in order to demonstrate the origin of the extra segment on the abnormal X chromosomes. All cases were identified as X-chromosome duplications by using a chromosome-specific painting probe. Application of appropriate locus-specific DNA probes as an adjunct to GTG- and RBG-banding proved useful in defining the breakpoints and the extent of the duplications. Although the… CONTINUE READING

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