Molecular cytogenetic evaluation of the aneugenic effects of teniposide in somatic and germinal cells of male mice.

@article{Attia2012MolecularCE,
  title={Molecular cytogenetic evaluation of the aneugenic effects of teniposide in somatic and germinal cells of male mice.},
  author={Sabry M Attia},
  journal={Mutagenesis},
  year={2012},
  volume={27 1},
  pages={
          31-9
        }
}
  • S. Attia
  • Published 2012
  • Biology
  • Mutagenesis
The ability of topoisomerase II inhibitor, teniposide, to induce aneuploidy and meiotic delay in somatic and germinal cells of male mice was investigated by fluorescence in situ hybridisation (FISH) assay using labelled DNA probes and 5-bromo-2'-deoxyuridine (BrdU) incorporation assay, respectively. Colchicine and mitomycin C were used as a positive control aneugen and clastogen, respectively, and these compounds produced the expected responses. Using FISH assay with centromeric and telomeric… 
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